C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2401367
The present invention provides a method for producing antibody fragments that discriminate between native and activated vitronectin, which can be used as markers of angiogenesis. Also provided are antibodies and peptides comprising said fragments, and therapeutic methods, particularly related to targeting for antibody-mediated antivascular cancer therapy and inhibiting the adhesion and migration of tumor-endothelial cells and platelets.
La présente invention concerne un procédé permettant de produire des fragments d'anticorps qui assurent une discrimination entre la vitronectine native et la vitronectine activée, et qui peuvent être utilisés comme traceurs de l'angiogénèse. L'invention traite également d'anticorps et de peptides comprenant ces fragments. Enfin, l'invention a aussi pour objet des procédés thérapeutiques, concernant le ciblage en matière de thérapie anti-cancéreuse des vaisseaux sanguins induite par les anticorps, et d'inhibition de l'adhérence et de la migration des plaquettes et des cellules tumorales endothéliales.
Bloemendal Henri Johan
de Boer Henriette Christine
Gebbink Martijn Frans Ben Gerard
Logtenberg Ton
Voest Emile Eugene
Borden Ladner Gervais Llp
Crucell Holland B.v.
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