Activating c1- secretion

Details Activating c1- secretion Activating c1- secretion

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 31/41 (2006.01) A61K 31/4164 (2006.01) A61K 31/655 (2006.01)

Patent

CA 2308769

Compounds represented by formula (I), wherein A is a 5 or 6-membered unsaturated heterocyclic ring containing at least one N atom; B is (a), NO2, N(R2)2, X2 is O, NH, NR, CH2, CHR or CR2, each R individually is alkyl, cycloalkyl, aryl, alkaryl and aralkyl, each R2 individually is H, alkyl, cycloalkyl, aryl, alkaryl, and aralkyl; Y is a halogen; alkythio group or nitrogenous moiety, are useful for activating Cl- secretion, and can be used for treating cystic fibrosis.

La présente invention concerne des composés représentés par la formule (I): dans laquelle A est un noyau hétérocyclique insaturé à 5 ou 6 chaînons renfermant au moins un atome N; B est (a), NO¿2?, N(R?2¿)¿2?, X?2¿ étant O, NH, NR, CH¿2?, CHR ou CR¿2?, chaque R étant individuellement alkyle, cycloalkyle, aryle, alcaryle et aralkyle, chaque R?2¿ étant individuellement H, alkyle, cycloalkyle, aryle, alcaryle et aralkyle; et Y est un halogène, un groupe alkylthio ou un fragment azoté; lesquels composés permettent d'activer la sécrétion de Cl?-¿ et peuvent être utilisés pour traiter la mucoviscidose.

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