Activating extraction of demineralized bone matrix

Details Activating extraction of demineralized bone matrix Activating extraction of demineralized bone matrix

A - Human Necessities

61

K

A61K 35/32 (2006.01)

Patent

CA 2589930

Demineralized bone matric (DBM) and native bone morphogenetic protein (nBMP) are complex mixtures of non-collagenous bone proteins. These mixtures contain many of the BMPs that are available as recombinant molecules. Information regarding the presence in these materials of molecules that may affect the availability and activity of the BMPs is very limited. A chemical extraction of DBM, such as using alkali-urea produces a water soluble extractate which inhibits the osteogenic activity of DBM. Noggin, an extracellular BMP ligand antagonist is found in the water soluble extractate from DBM. Differential chemical extraction is a useful means of removing non-osteogenic, or osteogenic inhibitory molecules from DBM and nBMP.

La matrice osseuse déminéralisée (DBM) et la protéine morphogénétique osseuse native (nBMP) sont des mélanges complexes de protéines osseuses non collagènes. Ces mélanges contiennent plusieurs BMP disponibles sous forme de molécules recombinantes. Les informations relatives à la présence dans ces matériaux de molécules capables d'affecter la disponibilité et l'activité de ces BMP sont très limitées. Une extraction chimique de la DBM, par exemple, au moyen d'alcali-urée, produit un extrait hydrosoluble qui inhibe l'activité ostéogénique de la DBM. Noggin, un antagoniste de ligand BMP extracellulaire, a été détecté dans l'extrait hydrosoluble provenant de la DBM. L'extraction chimique différentielle est un moyen utile pour enlever les molécules inhibitrices ostéogéniques ou non-ostéogéniques des DBM et de nBMP.

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