C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 39/00 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2488876
This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions.
L'invention concerne des variants de la protéine tyrosine kinase et des variants d'acide nucléique, en particulier des variants de PDGFRA, qui sont des formes d'activation de ces molécules et sont liés aux néoplasmes et/ou au développement ou à la progression du cancer. L'invention concerne également des méthodes de diagnostic et de pronostic, et la mise au point de nouveaux agents thérapeutiques dans lesquels sont utilisés ces molécules et des fragments de celles-ci, ainsi que des kits d'utilisation de ces méthodes et de ces compositions.
Corless Christopher L.
Demetri George D.
Fletcher Jonathan A.
Heinrich Michael C.
Brigham And Women's Hospital
Dana-Farber Cancer Institute
Oregon Health & Science University
Smart & Biggar
The Government Of The United States D.b.a. The Department Of Vet
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