Activation and aggregation of human platelets and formation...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61L 15/40 (2006.01) A61L 27/38 (2006.01) C12N 13/00 (2006.01)

Patent

CA 2743841

Methods for forming activated platelet gels using nsPEF's and applying the activated gels to wounds, such as heart tissue after myocardial infarction. The platelets are activated by applying at least one nsPEF with a duration between about 10 picoseconds to 1 microsecond and electrical field strengths between about 10 kV/cm and 350 kV/cm.

La présente invention concerne des procédés pour former des gels de plaquettes activées en utilisant des nsPEF et en appliquant les gels activés sur des plaies, telles quun tissu cardiaque après un infarctus du myocarde. Les plaquettes sont activées en appliquant au moins un nsPEF ayant une durée comprise entre environ 10 picosecondes et 1 microseconde et des intensités de champ électrique comprises entre environ 10 kV/cm et 350 kV/cm.

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