Activation and protection of t-cells (cd4+ and cd8+) using...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 31/35 (2006.01) A61K 31/352 (2006.01) A61K 31/415 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 38/44 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 39/39 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2341742

The present invention relates to a method for facilitating activation of T- cells in a patient, comprising: identifying a patient in need of enhanced T- cell activity, administering an effective amount of a T-cell activating composition to the patient, and administering an effective amount of a compound that inhibits the production or release of intercellular reactive oxygen metabolites (ROM) to the patient. The present invention further relates to the use of H2-receptor agonists to augment the effectiveness of vaccines.

Un procédé d'activation des cellules T chez un patient consiste à identifier un patient nécessitant une activité accrue des cellules T, à administrer au patient une quantité efficace d'une composition activant les cellules T, et à administrer au patient une quantité efficace d'un composé qui inhibe la production ou la libération de métabolites d'oxygène réactif intercellulaire (MOR). La présente invention concerne également l'utilisation d'agonistes du récepteur H¿2? pour accroître l'efficacité des vaccins.

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