A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 31/70 (2006.01) A61K 31/7036 (2006.01) A61K 38/47 (2006.01) A61P 35/00 (2006.01) C07H 15/22 (2006.01)
Patent
CA 2081281
Activation of Glucuronide Prodrugs By Ligand-.beta.-Glucuronidase Conjugates for Chemotherapy Abstract of the Disclosure A method for enhancing the specificity of chemotherapy is disclosed. A monoclonal antibody that can bind antigens preferentially expressed on the surface of malignant cells is used to form a conjugate with the enzyme .beta.-glucuronidase. Glucuronide analogues of therapeutic drugs, possessing reduced toxicity and enhanced efficacy compared with the parent compound, are administered subsequent to the administration of the .beta.-glucuronidase-anitbody conjugate such that the glucuronide analogues are enzymatically converted to therapeutic agents at malignant cells that are able to bind .beta.-glucuronidase-monoclonal antibody conjugates.
Chern Ji-Wang
Roffler Steve R.
Tung Edward
Wang Shing-Ming
Yeh Ming-Yang
National Science Council
Rogers Law Office
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