Activation of growth factors by matrix vesicles

Details Activation of growth factors by matrix vesicles Activation of growth factors by matrix vesicles

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 31/00 (2006.01) A61K 31/557 (2006.01) A61K 31/565 (2006.01) A61K 31/59 (2006.01) A61K 35/32 (2006.01) A61L 27/54 (2006.01) A61L 31/16 (2006.01) C07K 14/495 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2187731

Latent growth factors such as TGF.beta. in tissue culture or healing wounds are converted to active form by matrix vesicle extract or through the medium of matrix vesicles stimulated with Regulator of Enhancing Factor (REF). REFs include 1,25-dehydroxy vitamin D and steroid hormones. Matrix vesicles having REF intercalated into the vesicle membrane are provided. Polymeric implant and cell culture scaffolding materials with matrix vesicles, matrix vesicle extract, REF or latent growth factor are also provided.

Des facteurs de croissance latents tels que le facteur transformant de croissance-.beta. dans des cultures tissulaires ou des lésions cicatrisantes sont convertis en une forme active par un extrait de vésicules matricielles ou par l'intermédiaire de vésicules matricielles stimulées par un régulateur de facteur stimulant (REF). On peut citer à titre de REF la 1,25-déhydroxy vitamine D anisi que des hormones stéroïdes. L'invention concerne également des vésicules matricielles présentant un REF intercalé dans la membrane de la vésicule. L'invention concerne également un implant et des matières d'échaffaudage de cultures cellulaires polymères avec des vésicules matricielles, un extrait de vésicules matricielles, un REF ou un facteur de croissance latent.

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