Activation of hcv-specific cells

Details Activation of hcv-specific cells Activation of hcv-specific cells

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01) A61P 31/14 (2006.01) C07K 14/18 (2006.01) C12N 15/51 (2006.01)

Patent

CA 2505611

The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4+ and CD8+ T cells. HCV-specific T cells are activated using fusion proteins comprising HCV NS3, NS4, NS5a, and NS5b polypeptides, polynucleotides encoding such fusion proteins, or polypeptide or polynucleotide compositions containing the individual components of these fusions. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.

L'invention concerne un procédé d'activation de lymphocytes T spécifiques du virus de l'hépatite C (VHC), notamment des lymphocytes T CD4?+¿ et CD8?+¿. Les lymphocytes T spécifiques du VHC sont activés au moyen de protéines de fusion comprenant des polypeptides du VHC NS3, NS4, NS5a, et NS5b, des polynucléotides codant lesdites protéines de fusion, ou des compositions polypeptidiques ou polynucléotidiques contenant les composants individuels de ces fusions. Le procédé de l'invention peut être utilisé dans des systèmes modèles pour développer des compositions immunogènes spécifiques du VHC, ainsi que pour immuniser un mammifère contre le VHC.

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