Activation of hcv-specific t cells

Details Activation of hcv-specific t cells Activation of hcv-specific t cells

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 31/70 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01) C07K 14/18 (2006.01) C12N 15/62 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2389206

The invention provides a method of activating hepatitis C virus (HCV)- specific T cells, including CD4+ and CD8+ T cells. HCV-specific T cells are activated using fusion proteins comprising HCV NS3, NS4, NS5a, and NS5b polypeptides, polynucleotides encoding such fusion proteins, or polypeptide or polynucleotide compositions containing the individual components of these fusions. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.

L'invention concerne un procédé d'activation de lymphocytes T spécifiques au virus de l'hépatite C (HCV), y compris des lymphocytes T CD4?+¿ et CD8?+¿. On active ces lymphocytes T spécifiques à HCV au moyen de protéines de fusion comprenant des polypeptides NS3, NS4, NS5a et NS5b de HCV, de polynucléotides codant ces protéines de fusion ou de compositions de polypeptides ou de polynucléotides contenant les constituants individuels de ces fusions. On peut mettre en application ce procédé dans des systèmes de modélisation afin de développer des compositions immunogènes spécifiques à HCV, ainsi que d'immuniser un mammifère contre HCV.

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