Activation of hcv-specific t cells

Details Activation of hcv-specific t cells Activation of hcv-specific t cells

A - Human Necessities

61

K

A61K 39/29 (2006.01)

Patent

CA 2636032

Methods for activating HCV-specific T cells are described. The methods utilize one or more administrations of HCV protein compositions, followed by one or more administrations of a viral vector comprising a nucleic acid encoding a least one HCV epitope that is present in the first composition. The protein compositions can further comprise an immunostimulatory nucleic acid and or other adjuvants and immune stimulatory compounds.

Cette invention concerne des procédés permettant d'activer des lymphocytes T spécifiques du virus de l'hépatite C (VHC). Ces procédés font appel à une ou plusieurs administrations de compositions de protéines VHC, suivies d'une ou plusieurs administrations d'un vecteur viral comprenant un acide nucléique codant au moins un épitope VHC présent dans la première composition. Les compositions de protéines peuvent également comprendre un acide nucléique immunostimulateur et/ou d'autres adjuvants et composés immunostimulateurs.

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