Activation of the cystic fibrosis transmembrane conductance...

Details Activation of the cystic fibrosis transmembrane conductance... Activation of the cystic fibrosis transmembrane conductance...

A - Human Necessities

61

K

A61K 31/352 (2006.01) A61P 1/18 (2006.01) A61P 5/48 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 15/08 (2006.01)

Patent

CA 2415894

Fluorescein and derivatives have use in the treatment of a disease of condition of a living animal body, including human, which disease is responsive to the activation of the cystic fibrosis transmembrane conductance regulator chloride channels, for instance cystic fibrosis, disseminated brocheiectasis, pulmonary infections, chronic pancreatitis, male infertility and long QT syndrome.

Selon l'invention, la fluorescéine et ses dérivés peuvent être utilisés dans le traitement d'une maladie ou d'un état pathologique dont souffre un animal ou un homme, qui réagit aux canaux à chlorure régulateurs de la perméabilité transmembranaire de la fibrose kystique, par exemple la fibrose kystique, la bronchiectasis disséminée, les infections pulmonaires, la pancréatite chronique, l'infertilité masculine et le syndrome du QT long.

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