Activator for peroxisome proliferator-activated receptor...

Details Activator for peroxisome proliferator-activated receptor... Activator for peroxisome proliferator-activated receptor...

C - Chemistry, Metallurgy

07

D

C07D 413/06 (2006.01) A61K 31/00 (2006.01) A61K 31/423 (2006.01) A61K 31/427 (2006.01) A61K 31/454 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 19/10 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2463569

A compound represented by the general formula (I): (I) (wherein A represents oxygen, sulfur, etc.; B1 represents nitrogen, etc.; B2 represents oxygen, etc.; X1 and X2 each represents oxygen, sulfur, a bond, etc.; Y represents a C1-8 alkylene chain; Z represents oxygen or sulfur; R1 represents optionally substituted aryl, etc.; R2 represents C2-8 alkyl, etc.; R3 represents C1-8 alkyl, C2-8 alkenyl, etc.; R4 and R5 each represents hydrogen, C1-8 alkyl, etc.; and R6 represents hydrogen, etc.; provided that Z and R3 are bonded to the benzene ring and X2 is not bonded to the benzene ring) or a salt of the compound; and a PPAR.delta. activator containing the compound or salt as an active ingredient.

Composé représenté par la formule (I) dans laquelle A représente oxygène, soufre ; B<sp>1 </sp>représente azote, B<sp>2</sp> représente oxygène ; X<sp>1</sp> et X<sp>2</sp> représentent chacun oxygène, soufre ou une liaison ; Y représente une chaîne alkylène C<sp>1-8 </sp>; Z représente oxygène ou soufre ; R<sp>1</sp> représente aryle éventuellement substitué ; R<sp>2</sp> représente alkyle C<sp>2-8 </sp>; R<sp>3</sp> représente alkyle C<sp>1-8</sp>, alcényle C<sp>2-8 </sp>; R<sp>4</sp> et R<sp>5</sp> représentent chacun hydrogène, alkyle C<sp>1-8 </sp>et R<sp>6</sp> représente hydrogène, dans la mesure où Z et R<sp>3</sp> sont reliés au noyau benzène et X<sp>2</sp> n'est pas relié à ce noyau benzène. Sel de ce composé et activateur de PPAR.delta. contenant ce composé ou ce sel en tant qu'ingrédient actif.

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