Activator of peroxisome proliferator activated receptor d

Details Activator of peroxisome proliferator activated receptor d Activator of peroxisome proliferator activated receptor d

C - Chemistry, Metallurgy

07

D

C07D 413/06 (2006.01) A61K 31/42 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 15/00 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2614315

A compound represented by the general formula (II) below or a slat thereof is used as an activator of a PPAR .delta.. (In the formula, W3 represents a nitrogen atom or CH; Z1 represents an oxygen atom or a sulfur atom; R11 and R12 respectively represent a hydrogen atom, a halogen atom, an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, or an alkyl group substituted with a halogen atom and having 1-8 carbon atoms; R13 and R14 respectively represent a hydrogen atom of an alkyl group having 1-8 carbon atoms; A1 represents an optionally substituted pyrazole or a thiophene; and m represents an integer of 2-4.)

La présente invention concerne un composé représenté par la formule générale (II) ou une lame de celui-ci, utilisé comme activateur d'un PPAR .delta.. (Dans la formule, W3 représente un atome d'azote ou un CH ; Z1 représente un atome d'oxygène ou un atome de soufre ; R11 et R12 représentent respectivement un atome d'hydrogène, un atome d'halogène, un groupe alkyle ayant de 1 à 8 atomes de carbone, un groupe alcoxy ayant de 1 à 8 atomes de carbone ou un groupe alkyle substitué porteur d'un atome d'halogène et ayant de 1 à 8 atomes de carbone ; R13 et R14 représentent respectivement un atome d'hydrogène d'un groupe alkyle ayant de 1 à 8 atomes de carbone ; A1 représente un pyrazole ou un thiophène facultativement substitué ; et m représente un nombre entier de 2 à 4.)

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