Activator of peroxisome proliferator-activated receptor .delta.

Details Activator of peroxisome proliferator-activated receptor .delta. Activator of peroxisome proliferator-activated receptor .delta.

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 5/14 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 19/10 (2006.01) A61P 21/04 (2006.01) A61P 25/28 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 233/54 (2006.01) C07D 263/62 (2006.01) C07D 277/24 (2006.01) C07D 277/26 (2006.01)

Patent

CA 2457054

A compound represented by the following general formula (I): (see formula I) (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(=O), CH=CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-.delta. activator which contains the compound or salt as the active ingredient.

L'invention concerne un composé de formule générale (I), (dans laquelle R?1¿ représente phényle éventuellement substitué, etc., R?2¿ signifie alkyle C¿1-8?, etc., A désigne oxygène, etc., X représente une chaîne alkylène C¿1-8?, etc., Y signifie C(=O), etc., R?3¿, R?4¿ et R?5¿ désignent chacun hydrogène, alkyle C¿1-8?, etc., B représente CH, etc., Z signifie oxygène ou soufre, R?6¿ et R?7¿ désignent chacun hydrogène, etc., R?8¿ signifie hydrogène, etc., dans la mesure où au moins un parmi R?3¿, R?4¿ et R?5¿ n'est pas hydrogène), ou un sel de ce composé. La présente invention porte également sur un activateur PPAR-.delta. contenant ce composé ou ce sel comme agent actif.

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