Activators of human pyruvate kinase

Details Activators of human pyruvate kinase Activators of human pyruvate kinase

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/18 (2006.01) A61P 35/00 (2006.01) C07D 211/54 (2006.01) C07D 215/36 (2006.01) C07D 265/36 (2006.01) C07D 277/64 (2006.01) C07D 295/26 (2006.01) C07D 311/70 (2006.01) C07D 317/62 (2006.01) C07D 319/18 (2006.01) C07D 321/10 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 495/14 (2006.01)

Patent

CA 2740148

Disclosed are pyruvate kinase M2 activators, which are bis sulfonamide piperazinyl and piperidinyl compounds of Formula (I), 2,4-disubstituted 4H- thieno[3,2-c]pyrrole-2-(substituted benzyl)pyridazin- 3 (2H) -ones of Formula (II) and 6-(3,4- dimethylphenylaminosulfonyl)-3,4-dihydro-1H-quinolin-2-one of formula (III), wherein L, R1, R2, R11 to R16, R21 and R22 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia.

La présente invention concerne des activateurs de la pyruvate kinase M2 (PKM2), qui sont des composés de bis-sulfamide-pipérazinyle de formule (I) et des 2,4-disubstituées-4H-thiéno[3,2-b]pyrrole-2-(benzyl-substituées)pyridazin-3(2H)ones de formule (II), où L et R1 à R16 sont tels que définis ici. Lesdits activateurs peuvent être utilisés dans le cadre du traitement d'un certain nombre de maladies pouvant être traitées par l'activation de PKM2, par exemple, le cancer et l'anémie, formules (I); (II).

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