Active agent containing hydrogel devices wherein the active...

Details Active agent containing hydrogel devices wherein the active... Active agent containing hydrogel devices wherein the active...

A - Human Necessities

61

K

167/166

A61K 9/22 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 1246447

ACTIVE AGENT CONTAINING HYDROGEL DEVICES WHEREIN THE ACTIVE AGENT CON- CENTRATION PROFILE CONTAINS A SIGMOIDAL CONCENTRATION GRADIENT FOR IMPROVED CONSTANT RELEASE, THEIR MANUFACTURE AND USE ABSTRACT OF THE DISCLOSURE An active agent containing controlled release diffusion device compri- sing a swellable hydrogel matrix in the non-swollen state, interpene- trated with an active agent solute having a stable concentration distri- bution increasing in a gradient normal to the surface of the device and between the surface and the core thereof, said gradient being in the form of a substantially continuous, inflection point containing, sig- moidal curve, such that the device, when placed in an aqueous hydrogel swelling environment, releases said active agent in a controlled con- tinuous manner by diffusion for a predetermined period of time, a method of preparing such a device, and the use thereof to release an active agent into the intended environment of use.

481011

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