Active agent eluting matrices with particulates

Details Active agent eluting matrices with particulates Active agent eluting matrices with particulates

A - Human Necessities

61

L

A61L 27/44 (2006.01) A61L 27/54 (2006.01) A61L 31/12 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2656191

The present invention is directed to polymeric matrices for the controlled release of a hydrophilic bioactive agent. Generally, the elution control matrix includes a polymeric matrix having a first polymer and a plurality of microparticles that include the hydrophilic bioactive agent. In one embodiment, the matrix includes a polymer comprising hydrophilic and hydrophobic portions. In another embodiment, the microparticles include a crosslinked hydrophilic polymer.

L'invention concerne des matrices polymères destinées à libérer de manière commandée un agent bioactif hydrophile. De manière générale, la matrice à régulation d'élution comprend une matrice polymère présentant un premier polymère et une pluralité de microparticules qui comprennent un agent bioactif hydrophile. Dans un mode de réalisation de l'invention, la matrice comprend un polymère comportant des parties hydrophiles et hydrophobes. Dans un autre mode de réalisation de l'invention, les microparticules comprennent un polymère hydrophile réticulé.

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