Active carbonates of polyalkylene oxides for modification of...

Details Active carbonates of polyalkylene oxides for modification of... Active carbonates of polyalkylene oxides for modification of...

C - Chemistry, Metallurgy

12

N

C12N 9/00 (2006.01) A61K 38/43 (2006.01) A61K 47/48 (2006.01) C07D 207/46 (2006.01) C07D 209/50 (2006.01) C07D 209/76 (2006.01) C07D 211/94 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07K 14/765 (2006.01)

Patent

CA 2053317

Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.

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