Active component of parathyroid hypertensive factor

Details Active component of parathyroid hypertensive factor Active component of parathyroid hypertensive factor

C - Chemistry, Metallurgy

12

P

C12P 21/02 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/29 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/635 (2006.01) C07K 16/18 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2137829

2137829 9325577 PCTABScor01 An active component of parathyroid hypertensive factor which comprises a polypeptide linked to a phospholipid has been identified. The component exhibits activities substantially similar to parathyroid hypertensive factor and therefore is indicated in the control of extracellular calcium uptake, and is related to hypertension and some other diseases in mammals. Methods for screening patients for the presence of the circulating factor using antibodies against the component are described. Antagonists of the parathyroid hypertensive factor component have been developed and the use of such antagonists in methods of treating patients with diseases which involve intracellular calcium elevation are also described.

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