Active derivatives of methylamine, therapeutic compositions...

A - Human Necessities – 61 – K

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A61K 31/13 (2006.01) A61K 31/395 (2006.01) A61K 31/535 (2006.01) C07D 203/08 (2006.01) C07D 205/04 (2006.01) C07D 295/03 (2006.01) C07D 295/15 (2006.01)

Patent

CA 1076482

ABSTRACT OF THE DISCLOSURE: A pharmaceutical or veterinary composition for use in the treatment of Parkinson's disease and the correction of extra-pyramidal disturbances provoked by neuroleptics. This composition comprises, as essential active ingredient, at least one compound represented by the general formula : Image or a pharmaceutically acceptable acid addition salt thereof, wherein R1 and R3, which are the same or different , each represent a branched-or straight- chain alkyl radical having 3 or 4 carbon atoms, R4 represents hydrogen or a branched- or straight- chain alkyl, alkenyl or alkynyl radical having from 1 to 5 carbon atoms and R5 represents a branched- or straight- chain alkyl, alkenyl or alkynyl radical having from 1 to 5 carbon atoms, with the proviso that: - when R4 represents hydrogen, R5 is other than methyl or propargyl - when R4 represents propargyl, R5 is other than propargyl. This compound is in association with a pharmaceutical carrier or excipient therefor.

279749

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