Active drug delivery in the gastrointestinal tract

Details Active drug delivery in the gastrointestinal tract Active drug delivery in the gastrointestinal tract

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61B 5/07 (2006.01) A61K 9/00 (2006.01) A61B 5/00 (2006.01) A61J 3/07 (2006.01) A61M 31/00 (2006.01)

Patent

CA 2514392

Apparatus (100) for drug (36, 106) administration is provided, including an ingestible capsule (30, 102). The capsule (30, 102) includes a drug (36, 106), stored by the capsule (30, 102). An environmentally-sensitive mechanism (e.g., coating 104) is adapted to change a state thereof responsive to a disposition of the capsule (30, 102) within a gastrointestinal tract of a subject. A driving mechanism (e.g., driving mechanism 108), in response to a change of state of the environmentally-sensitive mechanism, is adapted to drive the drug (36, 106) directly through an endothelial layer of the gastrointestinal tract.

La présente invention concerne un appareil (100) destiné à l'administration de médicament (36, 106), qui comprend une gélule à ingérer (30, 102). Cette gélule (30, 102) comprend un médicament (36, 106) stocké par cette gélule (30, 102). Un mécanisme sensible à l'environnement (par exemple un film 104) est conçu de façon à changer d'état en réaction à une disposition de la gélule (30, 102) à l'intérieur du tube digestif d'un sujet. Un mécanisme d'entraînement (par exemple le mécanisme d'entraînement 108 ), en réponse à un changement d'état du mécanisme sensible à l'environnement, est conçu de façon à entraîner le médicament (36, 106) directement à travers une couche endothéliale du tube digestif.

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