Active fragments of fibroblast growth factor

Details Active fragments of fibroblast growth factor Active fragments of fibroblast growth factor

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) C07K 14/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2055961

31,309-00 FIBROBLAST GROWTH FACTOR FRAGMENTS ABSTRACT OF THE INVENTION The present invention relates to novel fragments of basic fibroblast growth factor (bFGF). The mitogenic potency of one of these bFGF fragments, identified as HBF-2 is about 25-50 fold less than that of native bFGF but at least 103-104 fold more active than that of previously reported synthetic fragments of bFGF. Therefore, the present invention provide the shortest fragment of bFGF that retains substantial biologic activity.

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