Active immunization to generate antibodies to soluble a-beta

Details Active immunization to generate antibodies to soluble a-beta Active immunization to generate antibodies to soluble a-beta

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 5/00 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2513722

The invention provides methods useful for effecting prophylaxis or treatment of Alzheimer's disease. Such methods entail administering A-beta fragments from a central or C-terminal regions of A-beta. Such fragments can induce a polyclonal mixture of antibodies that specifically bind to soluble A-beta without binding to plaques. The antibodies can inhibit formation of amyloid deposits of A-beta in the brain of a patient from soluble A.beta. thus preventing or treating the disease. Fragment A-beta 15-24 and subfragments of 5-10 contiguous amino acids thereof are preferred immunogens due to their capacity to generate a high titer of antibodies.

L'invention concerne des méthodes utiles de prophylaxie ou de traitement de la maladie d'Alzheimer. De telles méthodes consistent à administrer des fragments de A-beta issus de régions centrales ou C-terminales de A-beta. De tels fragments peuvent induire un mélange polyclonal d'anticorps se liant de manière spécifique à A-beta soluble sans se lier à des plaques. Les anticorps peuvent inhiber la formation de dépôts amyloïdes de A-beta dans le cerveau d'un patient à partir de A.beta. soluble, prévenant ou traitant ainsi la maladie. Un fragment A-beta 15-24 et des sous-fragments comprenant entre 5 et 10 acides aminés contigus sont, par conséquent, des immunogènes préférés, en raison de la capacité de ceux-ci de produire un titre élevé d'anticorps.?¿

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