Active or passive immunization against proapoptotic...

Details Active or passive immunization against proapoptotic... Active or passive immunization against proapoptotic...

A - Human Necessities

61

K

A61K 39/385 (2006.01) A01K 67/027 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2532759

The present invention relates to novel methods for combatting cell degeneration or dysfunction resulting from neuroinflammatory conditions. The invention especially relates to the use, in the preparation of a medicament for the treatment of neurodegenerative disease associated with neuroinflammation, of an immunogenic compound which is capable of inducing an immune response against a proapoptotic neurotrophin, or an effective amount of a hapten combined with appropriate carriers and/or adjuvants to render the resulting combination capable of inducing an immune response against a proapoptotic neurotrophin. Also disclosed are compositions for the active or passive immunization against neuronal or glial cell apoptosis caused by neuroinflammantion as well as methods and means useful for said active or passive immunization.

La présente invention concerne de nouveaux procédés pour combattre une dégénération ou un dysfonctionnement cellulaire résultant de pathologies neuroinflammatoires. Elle concerne notamment l'utilisation, dans la préparation d'un médicament pour traiter une maladie neurodégénérative associée à une neuroinflammation, d'un composé antigénique qui peut induire une réponse immunitaire contre une neurotrophine proapoptotique ou d'une quantité efficace d'un haptène combiné à des porteurs adéquats et/ou à des adjuvants afin de rendre la combinaison capable d'induire une réponse immunitaire contre une neurotrophine proapoptotique. La présente invention concerne également des compositions destinées à l'immunisation active ou passive contre une apoptose de cellules neuronales ou gliales causée par une neuroinflammation, ainsi que des procédés et des moyens utilisés pour cette immunisation active ou passive.

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