A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/22 (2006.01) A61K 9/20 (2006.01)
Patent
CA 2189991
A process for the production of devices for the controlled release of active substances, consisting of an active substance-containing matrix and an erodible mass of solids at least partially covering the matrix, with the thickness of the erodible mass across its extension being determined by thickness gradients, and the active substance-containing matrix itself being produced with thickness gradients which determine the thickness gradients of the erodible mass, is characterized in that in a first step the active substance-containing matrix is formed in the form of pressed articles having thickness gradients, and in a second step It is transferred onto a laminated tablet-compressing machine where it is compressed with the erodible mass.
Un procédé permet de produire des dispositifs de libération contrôlée de principes actifs, constitués d'une matrice qui contient le principe actif et d'une substance solide susceptible de s'éroder qui recouvre au moins en partie la matrice. L'épaisseur de la substance susceptible de s'éroder est déterminée par des gradients d'épaisseur dans le sens de son extension. Le procédé se caractérise en ce que la substance susceptible de s'éroder est unie à la matrice après la production de celle-ci.
Blake Cassels & Graydon Llp
Lts Lohmann Therapie-Systeme Ag
Lts Lohmann Therapie-Systeme Gmbh
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