Active-substance patch for releasing estradiol to the skin

Details Active-substance patch for releasing estradiol to the skin Active-substance patch for releasing estradiol to the skin

A - Human Necessities

61

K

A61K 47/22 (2006.01) A61K 9/70 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2156746

An active substance patch releasing estradiol to the skin is charac- terized by the fact that it consists of a backing layer and an at- tached active substance reservoir which comprises pressure sensi- tive adhesive and in which the active substance is at least partially soluble, and of a removable protective layer covering the adhesive film, the active substance reservoir being a polymer matrix which - in order to improve the bioavailability of the estradiol - comprises an added penetration enhancer of the general formula: Image wherein R = -CH2OH or -CH2-O-CH2-CHOH-CH2OH.

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