Active variants of fgf with improved specificity

Details Active variants of fgf with improved specificity Active variants of fgf with improved specificity

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) C07K 14/50 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2427477

The present invention provides active fibroblast growth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3 (FGFR3) triggering intracellular downstream mechanisms leading to activation of a biological response. Methods of utilizing preferred FGF mutants in preparation of medicaments for the treatment of malignancies and skeletal disorders including osteoporosis and enhancing fracture healing and wound healing processes are provided.

L'invention porte sur des variants actifs de facteurs de croissance de fibroblastes qui présentent une spécificité améliorée des sous-types de récepteurs. Les nouveaux variants préférés restent liés au type 3 de récepteur de FGF (FGFR3), déclenchant des mécanismes en aval intracellulaires qui entraînent l'activation d'une réponse biologique. L'invention porte également sur des méthodes d'utilisation de mutants de FGF préférés dans la préparation de médicaments pour traiter des tumeurs malignes et des maladies osseuses, comme l'ostéoporose, et pour stimuler le processus de cicatrisation des fractures et de guérison des blessures.

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