Activity-dependent neurotrophic factor

Details Activity-dependent neurotrophic factor Activity-dependent neurotrophic factor

C - Chemistry, Metallurgy

07

K

C07K 14/48 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/18 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2109098

The present invention relates to a purified non-neuronal activity-dependent neurotrophic factor (ADNF) protein that increases the survival of spinal cord neuron cells, cerebral cortical cells and hippocampal neuron cells which has a molecular weight of 16,000 to 18,000 Daltons as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis, and a basic pI of about 8.1. The protein of the present invention can be used in the treatment of neurological deficiencies and for the prevention of AIDS related neuronal cell death.

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