C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/22 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2349159
The present invention relates generally to Activity Dependent Neurotrophic Factor III (ADNF III), also known as Activity Dependent Neuroprotective Protein (ADNP). More particularly, the present invention relates to nucleic acid sequences encoding ADNF III polypeptides; ADNF III polypeptides encoded by such nucleic acid sequences; antibodies to ADNF III polypeptides; and methods of using such ADNF III polypeptides for the treatment of neurological deficiencies and for the prevention of cell death associated with (1) gp120, the envelope protein from HIV; (2) N-methyl-D-aspartic acid (excito-toxicity); (3) tetrodotoxin (blockage of electrical activity); and (4) .beta.-amyloid peptide, a substance related to neuronal degeneration in Alzheimer's disease.
L'invention concerne, d'une manière générale, le facteur neurotrophique III dépendant de l'activité (ADNF III), également connu sous le nom de protéine neurotrophique dépendante de l'activité (ADNP). L'invention concerne plus particulièrement des séquences nucléotidiques codant les polypeptides d'ADNF III, les polypeptides d'ADNF III codés par lesdites séquences nucléotidiques; des anticorps des polypeptides d'ADNF III; et des procédés d'utilisation desdits polypeptides d'ADNF III dans le traitement des déficiences neurologiques et la prévention de la mort cellulaire dus à: 1) gp120, la protéine d'enveloppe provenant du VIH; 2) acide N-méthyl-D-aspartique (excitotoxicité); 3) tétrodotoxine (blocage de l'activité électrique) et; 4) peptide .beta.-amyloïde, substance liée à la dégénérescence neuronale lors de la maladie d'Alzheimer.
Bassan Merav
Brenneman Douglas E.
Gozes Illana
Zamostiano Rachel
Fetherstonhaugh & Co.
Ramot At Tel Aviv University Ltd.
Ramot University Authority For Applied Research And Industrial D
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
LandOfFree
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