C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2574777
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuron. The present invention also provides methods of screening compounds that modulate activity of an ActRII protein and/or an ActRII ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRII protein and/or an ActRII ligand.
Dans certains aspects, l'invention concerne des compositions et de procédés permettant de moduler (favoriser ou inhiber) la croissance d'un tissu, comme un os, un cartilage, un muscle, une graisse et/ou un neurone. L'invention concerne également des procédés de criblage de composés modulant l'activité d'une protéine ActRII et/ou d'un ligand ActRII. Lesdites compositions et lesdits procédés s'utilisent dans le traitement de maladies associées à une activité anormale d'une protéine ActRII et/ou d'un ligand ActRII.
Knopf John
Seehra Jasbir
Acceleron Pharma Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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