Acute pharmacologic augmentation of psychotherapy with...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/42 (2006.01) A61K 31/00 (2006.01) A61K 31/132 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/535 (2006.01) A61K 45/00 (2006.01) A61P 25/14 (2006.01) A61P 25/22 (2006.01) A61P 25/30 (2006.01)

Patent

CA 2442330

Methods for treating an individual with a psychiatric order with a pharmacologic agent that enhances learning or conditioning in combination with a session of psychotherapy are provided. These methods of the invention encompass a variety of methods of psychotherapy, and psychodynamically oriented psychotherapy, and psychiatric orders including fear and anxiety disorders, addictive disorders, addictive disorders including substance-abuse disorders, and mood disorders. The pharmacologic agents used for the methods of the present invention are ones that generally enhance learning or conditioning, including those that increase the level of norepinephrine in the brain, those that increase the level of acetylcholine in the brain, and those that enhance N-methyl-D-aspartate(NMDA) receptor transmission in the brain.

L'invention concerne des méthodes permettant de traiter un sujet à caractère psychiatrique avec un agent pharmacologique qui active l'apprentissage ou le conditionnement, en combinaison avec une séance de psychothérapie. Ces méthodes regroupent une variété de méthodes de psychothérapie, y compris la psychothérapie par exposition, la psychothérapie cognitive et la psychothérapie à orientation psychodynamique, et les ordres psychiatriques comprenant les troubles liés à la peur et à l'anxiété, les troubles liés à la dépendance, y compris les troubles liés à l'abus de substances et les troubles de l'humeur. Les agents pharmacologiques utilisés pour appliquer ces méthodes sont ceux qui activent de manière générale l'apprentissage ou le conditionnement, y compris celles qui élèvent le niveau de norépinéphrine dans le cerveau, le niveau d'acétylcholine et celles qui activent la transmission du récepteur N-méthyl-D-aspartate (NMDA) dans le cerveau.

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