Acute treatment of social phobia

A - Human Necessities – 61 – L

Patent

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Details

A61L 9/04 (2006.01) A61K 31/57 (2006.01)

Patent

CA 2621486

Methods and compositions for the treatment of social phobia are provided, including administering a therapeutically effective amount of an androsta-4,16- dien-3-ol steroid to an individual in need of treatment and a pharmaceutical composition for the treatment of social phobia having a therapeutically effective amount of an androsta-4,16-dien-3-ol steroid. Therapeutically effective amounts may be, for example, between about 100 picograms and about 100 micrograms, or between about 1 nanogram and about 10 microgram, or between about 10 nanograms and about 1 microgram of an androsta-4,16-dien-3-ol steroid. Administration of the androsta-4,16-dien-3-ol compound is preferably intranasal administration to the nasal passages and the vomeronasal organ of the individual. A preferred androsta-4,16-dien-3-ol steroid is [3.beta.]- androsta-4,16-dien-3-ol. In some embodiments of the methods, both [3.beta.}- androsta- 4,16-dien-3-ol and [3.alpha.]-androsta-4,16-dien-3-ol are administered to a patient, and are included in a pharmaceutical composition for the treatment of social phobia.

L'invention porte sur des méthodes et des compositions de traitement de la phobie sociale consistant à administrer à un individu le nécessitant une quantité thérapeutiquement efficace de stéroïde d'androsta-4,16-dien-3-ol et sur une préparation pharmaceutique de traitement de la phobie sociale comprenant une quantité thérapeutiquement efficace de stéroïde d'androsta-4,16-dien-3-ol. Les doses à effet thérapeutique sont par exemple comprises entre environ 100 picogrammes et environ 100 microgrammes, ou environ entre 1 nanogramme et environ 10 microgrammes, ou entre environ 10 nanogrammes et environ 1 microgramme d'un stéroïde d'androsta-4,16-dien-3-ol. L'administration du composé d'androsta-4,16-dien-3-ol est de préférence via les narines et l'organe voméronasal. L'un des stéroïdes d'androsta-4,16-dien-3-ol est le [3ß]-androsta-4,16-dien-3-ol. Dans certaines exécutions, on administre à la fois le [3ß}- androsta- 4,16-dien-3-ol et le [3a]-androsta-4,16-dien-3-ol tous deux inclus dans une même préparation pharmaceutique.

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