Acutumine and acutumine compounds, synthesis and use

Details Acutumine and acutumine compounds, synthesis and use Acutumine and acutumine compounds, synthesis and use

C - Chemistry, Metallurgy

07

D

C07D 209/96 (2006.01) A61K 31/403 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2491214

The invention relates to acutumine and compounds thereof and also to compounds of formula (I) wherein Rl and R2 each represent a hydrogen atom or together form an additional bond, R3 represents a hydrogen atom or an alkoxy group, R3 represents a hydrogen or chlorine atom, R6 represents a hydrogen atom or an alkyl, alkylcarbonyl or amyl group, R7 and R10 each represent an alkoxy group, RIO represents an alkoxy group, R4, R8, R9, R11, R12, R13 and R14 are as defined in the description.

L'invention se rapporte à l'acutumine, à des composés de l'acutumine ainsi qu'à des composés de formule (I) dans laquelle : R¿1? et R¿2? représentent chacun un atome d'hydrogène ou forment conjointement une liaison supplémentaire ; R¿3? représente un atome d'hydrogène ou un groupe alkoxy ; R¿5? représente un atome d'hydrogène ou de chlore ; R¿6? représente un atome d'hydrogène ou un groupe alkyle, alkylcarbonyle ou aroyle ; R¿7? et R¿10? représentent chacun un groupe alkoxy ; R¿10? représente un groupe alkoxy ; R¿4?, R¿8?, R¿9?, R¿11?, R¿12?, R¿13? et R¿14? ont leur signification indiquée dans la description. Cette invention concerne en outre des médicaments.

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