Acyclic amine inhibitors of 5'-methylthioadenosine...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2662626

The present invention relates to compounds of the general formula (I) which are inhibitors of 5'-methylthioadenosine phosphorylase or 5'-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5'-methylthioadenosine phosphorylase or 5'-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.

L'invention concerne des composés de la formule générale (I) qui sont des inhibiteurs de la 5'-méthylthioadénosine phosphorylase ou de la 5'-méthylthioadénosine nucléosidase. L'invention se rapporte également à l'utilisation des composés précités dans le traitement de maladies ou états dans lesquels il est souhaitable d'inhiber la 5'-méthylthioadénosine phosphorylase ou la 5'-méthylthioadénosine nucléosidase, y compris le cancer, et à des compositions pharmaceutiques contenant lesdits composés.

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