C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 17/06 (2006.01) A61P 31/04 (2006.01) A61P 33/02 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2662628
The invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNPs) and/or nucleoside hydrolases (NHs). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
La présente invention concerne des composes représentés par la formule générale (I), et des compositions pharmaceutiques contenant ces composés, lesquels composés sont des inhibiteurs des phosphorylases de nucléosides de purine (PNP) et/ou d'hydrolases de nucléosides (NH). L'invention concerne également l'utilisation de ces composés pour le traitement de maladies et d'infections dont le cancer, les infections bactériennes, les infections par protozoaires, et les maladies médiées par les lymphocytes T.
Clinch Keith
Evans Gary Brian
Furneaux Richard Hubert
Gulab Shivali Ashwin
Kelly Peter Michael
Albert Einstein College Of Medicine Of Yeshiva University
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Industrial Research Limited
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