Acyclic hydrazides as cannabinoid receptor modulators

Details Acyclic hydrazides as cannabinoid receptor modulators Acyclic hydrazides as cannabinoid receptor modulators

C - Chemistry, Metallurgy

07

C

C07C 243/24 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) A61K 31/44 (2006.01) C07C 255/00 (2006.01) C07D 213/02 (2006.01)

Patent

CA 2582588

The acyclic hydrazides of the invention are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson~s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders (including smoking cessation), the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo- obstruction, and cirrhosis of the liver.

L'invention concerne des hydrazides acycliques qui sont des antagonistes et/ou des agonistes inverses du récepteur cannabinoïde-1 (CB1) et qui sont utiles pour le traitement, la prévention et la suppression de maladies médiées par le récepteur CB1. Les composés selon l'invention sont utiles en tant que médicaments à action centrale pour le traitement: des psychoses, des déficits de mémoire, des troubles cognitifs, de la migraine, des neuropathies, des troubles neuroinflammatoires dont la sclérose en plaques et le syndrome de Guillain-Barre, des séquelles inflammatoires de l'encéphalite virale, des accidents vasculaires cérébraux, des traumatismes crâniens, de l'anxiété, du stress, de l'épilepsie, de la maladie de Parkinson, des troubles de la locomotion et de la schizophrénie. Ils s'avèrent également utiles pour le traitement de la toxicomanie (notamment la désaccoutumance au tabac), de l'obésité, des troubles de la nutrition, de l'asthme, de la constipation, des pseudo-obstructions intestinales chroniques et de la cirrhose du foie.

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