Acyclic linker-containing oligonucleotides and uses thereof

C - Chemistry – Metallurgy – 07 – H

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C07H 21/00 (2006.01) A61K 48/00 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2465129

Oligonucleotides having an internal acyclic linker residue, and the preparation and uses thereof, are described. Such uses include the preparation of acyclic linker-containing antisense oligonucleotides, and their use for the prevention or depletion of function of a target nucleic acid of interest, such as RNA, in a system. Such a prevention or depletion of .function includes, for example, the prevention or inhibition of the expression, reverse transcription and/or replication of the target nucleic acid, as well as the cleavage/degradation of the target nucleic acid. Accordingly, an oligonucleotide of the invention is useful for analytical and therapeutic methods and uses in which the function of a target nucleic acid is implicated, as well as a component of commercial packages corresponding to such methods and uses.

L'invention concerne des oligonucléotides comportant un résidu lieur acyclique interne, leur préparation et leurs utilisations. Ces utilisations comprennent la préparation d'oligonucléotides antisens contenant un lieur acyclique et leur utilisation pour la prévention ou l'appauvrissement de fonction d'un acide nucléique cible d'intérêt, tel qu'un ARN, dans un système. Une telle prévention ou appauvrissement de fonction comprend, par exemple, la prévention ou l'inhibition de l'expression, de la transcription inverse et/ou de la replication de l'acide nucléique cible, ainsi que la scission/dégradation de cet acide nucléique. En conséquence, un oligonucléotide de l'invention est utile dans des procédés analytiques et thérapeutiques et dans des utilisations dans lesquels la fonction d'un acide nucléique cible est impliquée, ainsi que comme composant de trousses commerciales correspondant à ces procédés et utilisations.

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