Acyclic metalloprotease inhibitors

Details Acyclic metalloprotease inhibitors Acyclic metalloprotease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 323/60 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/351 (2006.01) A61K 31/382 (2006.01) A61K 31/4035 (2006.01) A61K 31/4172 (2006.01) A61K 31/426 (2006.01) A61K 31/4406 (2006.01) A61K 31/455 (2006.01) A61K 31/495 (2006.01) A61K 31/5375 (2006.01) A61K 31/664 (2006.01) A61P 19/02 (2006.01) A61P 35/04 (2006.01) C07C 259/06 (2006.01) C07C 311/14 (2006.01) C07C 311/19 (2006.01) C07C 311/29 (2006.01) C07C 317/48 (2006.01) C07C 323/61 (2006.01) C07D 207/412 (2006.01) C07D 209/48 (2006.01) C07D

Patent

CA 2298617

The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically- acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

L'INVENTION CONCERNE DES COMPOSéS DE LA FORMULE (I) TELLE QUE DéCRITE DANS LES REVENDICATIONS, OU UN ISOMèRE OPTIQUE, UN DIASTéRéOMèRE OU UN éNANTIOMèRE, UN SEL ACCEPTABLE DU POINT DE VUE PHARMACEUTIQUE, UN AMIDE, UN ESTER OU UN IMIDE POUVANT êTRE BIOHYDROLYSé, DE CES COMPOSéS, S'UTILISANT COMME INHIBITEURS DE MéTALLOPROTéASES. L'INVENTION CONCERNE EN OUTRE DES COMPOSITIONS PHARMACEUTIQUES ET DES MéTHODES DE TRAITEMENT DE MALADIES, DE TROUBLES ET D'AFFECTIONS SE CARACTéRISANT PAR UNE ACTIVITé DES MéTALLOPROTéASES, AU MOYEN DE CES COMPOSITIONS OU DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT.

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