Acyclic nucleoside derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 473/18 (2006.01) A61K 31/52 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A61P 31/22 (2006.01) C07D 473/00 (2006.01) C07D 473/32 (2006.01)

Patent

CA 2238516

Compounds of formula (I) where one of R1 and R2 is - C(O)CH(CH(CH3)2)NH2 or -C(O)CH(CH(CH3)CH2CH3)NH2; the other of R1 and R2 is -C(~O)C3-C21 saturated or monounsaturated, optionally substituted alkyl; and R3 is OH or H; and pharmaceutically acceptable salts thereof have utility as enhanced bioavailability antivirals against herpes and retroviral infections.

On décrit des composés de la formule (I) dans laquelle R1 ou R2 correspond à -C(O)CH(CH(CH3)2)NH2 ou -C(O)CH(CH(CH3)CH2CH3)NH2, tandis que l'autre élément correspond à un alkyle -C(=O)C3-C21 facultativement substitué, saturé ou monoinsaturé, et R3 correspond à OH ou H. On décrit également des sels pharmaceutiquement acceptables de ces composés, utiles comme antiviraux, à biodisponibilité renforcée, contre l'herpès et les infections par rétrovirus.

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