Acyclic pyrazole compounds

Details Acyclic pyrazole compounds Acyclic pyrazole compounds

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) C07D 401/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2510298

Compounds are described which inhibit mitogen activated protein kinase- activated protein kinase-2 (MK-2). Methods of making such compounds are described, as well as a method of using them for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNF.alpha., where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.

L'invention concerne des composés qui inhibent une protéine kinase activée par un mitogène/une protéine kinase 2 activée (MK-2). Cette invention a également pour objet des méthodes d'élaboration de tels composés, ainsi qu'une méthode visant à les utiliser pour inhiber une protéine kinase 2 (MK-2) et pour prévenir ou traiter une maladie ou un trouble à médiation TNF.alpha.. Ladite méthode consiste à administrer au sujet un composé d'inhibition de MK-2 de la présente invention. Cette invention a aussi trait à des compositions pharmaceutiques et à des kits qui renferment lesdits composés d'inhibition de MK-2.

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