Acyclovir derivatives for topical use

Details Acyclovir derivatives for topical use Acyclovir derivatives for topical use

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/52 (2006.01) A61K 31/675 (2006.01) C07H 19/04 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2222154

Compositions for topical use in herpes virus infections comprising anti-herpes nucleoside analogue phosphate esters, such as acyclovir monophosphate, acyclovir diphosphate, and acyclovir triphosphate which show increased activity against native strains of herpes virus as well as against resistant strains, particularly thymidine kinase negative strains of virus. Anti-herpes nucleoside analogues phosphate esters include the phosphoramidates and phosphothiorates, as well as polyphosphates comprising C and S bridging atoms.

L'invention porte sur des compositions à usage topique dans les infections dues au virus de l'herpès, comportant des esters phosphoriques d'analogues de nucléosides anti-herpès, tels que l'acyclovir monophosphate, l'acyclovir diphosphate, l'acyclovir triphosphate et qui présentent une activité accrue vis à vis des souches natives du virus de l'herpès et de souches résistantes et en particulier des souches de virus thymidine kinase négatives. Lesdits esters phosphoriques d'analogues de nucléosides anti-herpès comprennent les phosphoramidates et les phosphothiorates ainsi que des polyphosphates à atomes ponts en C et S.

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