Acyl and phosphate derivatives of 5,6-dihydro-5-azathymidine

Details Acyl and phosphate derivatives of 5,6-dihydro-5-azathymidine Acyl and phosphate derivatives of 5,6-dihydro-5-azathymidine

C - Chemistry, Metallurgy

07

H

260/229

C07H 19/12 (2006.01)

Patent

CA 1056822

ABSTRACT OF THE DISCLOSURE A new antibiotic U-44,590 known as 5,6-dihydro- 5-azathymidine and its derivatives are described. These anti- biotics are active against Gram-negative bacteria and can be used in various environments to eradicate or control such bacteria. This divisional application is particularly directed to acyl and phosphate derivatives of U-44,590 having the formula Image wherein R and R1 are selected from the group consisting of a carboxylic acid acyl radical of from 2 to 18 carbon atoms, inclusive; or a halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, and lower alkoxy-substituted hydrocarbon carboxylic acid acyl radical of from 2 to 18 carbon atoms, inclusive; R is hydrogen and R1 is as defined above or phosphate; or R1 is hydrogen and R is a carboxylic acid acyl radical of from 2 to 18 carbon atoms, inclusive; or a halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, and lower alkoxy-substituted hydrocarbon carboxylic acid acyl radical of from 2 to 18 carbon atoms, inclusive, or phosphate.

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