Acyl hydrazides as kinase inhibitors, in particular for sgk

Details Acyl hydrazides as kinase inhibitors, in particular for sgk Acyl hydrazides as kinase inhibitors, in particular for sgk

C - Chemistry, Metallurgy

07

C

C07C 243/40 (2006.01) A61K 31/166 (2006.01) A61P 3/00 (2006.01) C07C 243/38 (2006.01) C07C 255/57 (2006.01) C07C 323/62 (2006.01)

Patent

CA 2603475

Novel acyl hydrazides of the formula (I), in which R1 - R9 have the meanings defined in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions such as diabetes, obesity, metabolic syndrome (dyslipidemia), systemic and pulmonary hypertension, cardiovascular diseases and kidney diseases, and generally any types of fibroses and inflammatory processes.

L'invention concerne de nouveaux acylhydrazides de formule (I) dans laquelle R1 - R9 ont la signification indiquée dans la revendication 1. Ces nouveaux acylhydrazides constituent des inhibiteurs de la SGK et peuvent être utilisés pour le traitement de maladies liées à la SGK ainsi que des affections telles que le diabète, l'adiposité, le syndrome métabolique (dyslipidémie), l'hypertonie généralisée et pulmonaire, les maladies cardio-vasculaires et les maladies rénales, ainsi qu'en général tout type de fibroses et de processus inflammatoires.

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