C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/22 (2006.01) A61K 31/66 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01) A61P 37/02 (2006.01) C07C 323/60 (2006.01) C07F 9/09 (2006.01)
Patent
CA 2395197
The invention relates in particular to pseudodipeptides which are derived from functionalised aminoacids and which comprise fatty acid chains that are fixed on the amine functions of the pseudodipeptides in amide form, one of the ends of said pseudodipeptides having a functionalised auxiliary arm and the other end being a neutral or charged acid group. The inventive compounds have immunomodulatory properties when used as adjuvants. The inventive compounds can also be grafted onto an antigen in order to modulate the immune response or grafted onto a pharmacophore in order to improve its therapeutic action or its targeting. Finally, the inventive compounds can therefore be used in human and veterinary medicine as immunizing agents and as diagnostic tools.
L'objet de l'invention concerne spécifiquement des pseudodipeptides qui dérivent d'acides aminés fonctionnalisés, comportant des chaînes d'acides gras fixées sous forme d'amide sur les fonctions amine du pseudodipeptide et dont l'une des extrémités est porteuse d'un bras auxiliaire fonctionnalisé, l'autre extrémité étant un groupement acide sous forme neutre ou chargée. Les composés de la présente invention possédent des propriétés immunomodulatrices comme adjuvants. Les composés de l'invention peuvent en outre être greffés sur un antigène pour moduler la réponse immunitaire ou être également greffés sur un pharmacophore pour améliorer son action thérapeutique ou son ciblage. Les composés de l'invention trouvent de ce fait une utilisation en médecine humaine et vétérinaire comme agents immunisants et comme outil de diagnostic.
Bauer Jacques
Martin Olivier Richard
Rodriguez Sylvain
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Om Pharma
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