A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/22 (2006.01) A61K 31/24 (2006.01) A61K 31/27 (2006.01) A61K 31/445 (2006.01) C07C 307/06 (2006.01) C07C 311/18 (2006.01) C07D 211/28 (2006.01) A61K 31/17 (2006.01)
Patent
CA 2434491
A class of acyl sulfamides comprises compounds that are potent ligands for PPAR gamma and generally have antagonist or partial agonist activity. The compounds may be useful in the treatment, control or prevention of obesity, non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, vascular restenosis, inflammation, and other PPAR gamma mediated diseases, disorders and conditions.
L'invention concerne une classe d'acyl-sulfamides qui renferme des composés étant de puissants ligands pour PPAR gamma et présentent généralement une activité antagoniste ou partiellement agoniste. Les composés peuvent être utiles dans le traitement, la régulation ou la prévention de l'obésité, du diabète non insulinodépendant, de l'hyperglycémie, de la dyslipidémie, de l'hyperlipidémie, de l'hypercholestérolémie, de l'hypertriglycéridémie, de l'athérosclérose, de la resténose vasculaire, de l'inflammation et d'autres maladies, troubles et conditions induites par PPAR gamma.
Acton John J. III
Jones A. Brian
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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