Acyl transfer with stabilised transition complex using...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/54 (2006.01) A61K 39/00 (2006.01) C07K 1/04 (2006.01) C07K 1/10 (2006.01) C07K 1/113 (2006.01) C12N 9/10 (2006.01) C12N 11/02 (2006.01) C12P 1/00 (2006.01)

Patent

CA 2254987

The invention relates to a method of performing a chemical reaction between a reagent and a substrate, involving an acyl transfer mechanism, in the presence of an imidazole-based catalyst capable of forming a transition complex with the substrate. The catalytic imidazole function is provided by a chemical structure element comprising an optionally substituted imidazolyl group flanked on one or both sides by a group or groups capable of stabilizing the transition complex by molecular interaction with the acyl group. The invention also relates to such a designed chemical structure element, a method of producing it by recombinant DNA techniques and a vector therefor.

Procédé pour provoquer une réaction chimique entre un réactif et un substrat, par un mécanisme de transfert d'acyle, en présence d'un catalyseur à base d'imidazole capable de former un complexe de transition avec le substrat. La fonction catalytique de l'imidazole est assurée par un élément chimique comprenant un groupe imidazolyle éventuellement substitué comportant sur un côté ou sur les deux côtés un ou plusieurs groupes capables de stabiliser le complexe de transition par interaction moléculaire avec le groupe acyle. L'invention porte également sur un tel élément chimique, sur un procédé pour le produire par des techniques d'ADN recombiné et sur un vecteur correspondant.

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