A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/228
A61K 31/44 (2006.01)
Patent
CA 2004443
4484N ABSTRACT OF THE INVENTION The present invention relates to a method of inhibiting tumor metastasis in an animal by administering to an animal in need of such treatment an acylaminoalkylpyridineamides represented by the formula Image wherein: R1 and R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a Image group wherein n, m and p are independently an interger of from 1 to 8 provided n + m + p is equal to or less than 10; x is thio or sulfinyl; Alk1 is straight or branched 4484N chain lower alkylene of 1 to 6 carbon atoms, R3 is hydrogen or lower alkyl, Alk2 is straight or branched chain alkylene of 1 to 4 carbon atoms; R4 is selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl and lower alkoxy; or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit tumor metastasis.
Fuller George Charles
Martin George Reilly
Mueller Richard August
Reich Reuven
Department Of Health And Human Services (the) Government Of The United States Of America As Represented By The
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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