C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/253, 260/240
C07D 403/14 (2006.01) C07D 207/16 (2006.01)
Patent
CA 1161434
ABSTRACT Acylaminoquinazoline derivatives of formula (I): Image ( I ) (in which: R1 represents a lower alkoxy group, a substituted or unsubstituted lower alkyl group, a cycloalkyl group, a lower alkenyl group, a vinyl group having an optionally substituted phenyl or furyl substituent an optionally substituted phenyl group, a furyl group, an oxazolyl group, a methylthiooxadiazolyl group or a tetrahydrofuryl group: ABSTRACT: R2 represents a hydrogen atom or a lower alkyl group; R3 represents ~ lower alkyl group or an optionally substituted phenyl group; R4 represents a hydrogen atom ot an atyloxy- substituted phenyl group: X represents a methylene group or a sulphur atom; and n 15 2 or 3) and pharmaceutically acceptable acid addition salts thereof are valuable antihypertensive agents and inhibit the activity of the angiotension I-converting enzyme. They may be prepared by reacting a 4-ominoquinazoline derivative with a carboxylic acid or reactive derivative thereof corresponding to the amide group which it is desired to introduce at the 4- popsition of said compound of formula (I). The compounds of the invention may b- formulated with conventional pharmaceutically acceptable carriers or diluents to provide a pharmaceutical composition.
390963
Fukumi Hiroshi
Kitahara Nobuaki
Koike Hiroyuki
Sato Yasunobu
Marks & Clerk
Sankyo Company Limited
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