C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/40 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/4439 (2006.01) A61P 25/28 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2528496
This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula (I). The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting .beta.-amyloid peptide release and/or synthesis, a method for inhibiting .gamma.--secretase activity, and a method for treating neurological disorders associated with .beta.-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula (I). The compounds of Formula (I) are useful in the prevention and treatment of Alzheimer's disease. (see formula I)
L'invention concerne des amino acide amidyle pyrazoles acylés et des composés relatifs de formule (I). L'invention concerne également une formation pharmaceutique comprenant un tel composé ou sous la forme d'un sel acceptable sur le plan pharmaceutique de celui-ci. L'invention concerne en outre un procédé d'inhibition d'une libération et/ou synthèse du peptide .szlig.-amyloïde, un procédé d'inhibition de l'activité de la ?-secrétase et une méthode de traitement de troubles neurologiques associés à la production du peptide .szlig.-amyloïde. La méthode consiste à administrer à un hôte une formulation pharmaceutique renfermant une quantité efficace d'un composé de formule (I). Les composés de formule (I) sont utiles dans la prévention et le traitement de la maladie d'Alzheimer.
Dressen Darren
Garofalo Albert
Guinn Ashley C.
Jenkins Scott A.
Latimer Lee H.
Elan Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
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